New research suggests that individuals who stop using new GLP-1 drugs like Mounjaro or Wegovy may regain lost weight much more quickly than those who stop conventional lifestyle regimens.
Research printed in a leading medical journal points out that while obese people can lose substantial amounts of their body weight while undergoing treatment, the mass comes back at an average rate of nearly a kilo each month once they quit.
"Individuals buying such drugs need to be informed of the potential of quick rebound weight gain when the medication is stopped," stated lead investigator Dr. Susan Jebb.
That rate of recovery means a reversion to original mass within about 18 months.
Comparing Treatments
The research, which examined 37 of studies involving thousands of participants, compared the results of the injectable medications with conventional dieting.
Researchers note that people who shed pounds through dieting typically experience a slower creep back—approximately 100 grams monthly—once they finish.
Understanding the Rapid Rebound
Nutrition scientists propose the way of the injections is key to understanding the heightened regain.
The injections mimic a natural hormone called glucagon-like peptide-1, which moderates hunger.
"Sustained high doses of GLP-1 concentrations far above than normal might result in the body to produce less of its own natural GLP-1, and could lessen sensitivity to its actions," explained Dr. Adam Collins, a nutrition expert.
"Withdrawal of this hormone supplement results in appetite is no longer kept in check, making excessive eating much more probable."
A Lifelong Disease?
The NHS suggest the jabs for individuals with obesity-related health risks, alongside recommended diet and exercise modifications.
A number of clinicians say that, due to the high risk of weight regain, the therapy should be considered life-long.
This opinion is supported by drug manufacturers, who state that the findings "highlight the chronic character of excess weight," akin to managing conditions like diabetes.
User Testimonies
Users who have come off the medication describe a intense resurgence of hunger.
"It was like something activating and I was suddenly ravenous," described an individual.
The struggle is exacerbated if patients have not adopted sustainable dietary or behavioural changes during treatment.
Growing Interest
Figures show that millions of adults in the UK have used weight-loss jabs in the last 12 months, with desire remaining high.
- Use is greater among women compared to men.
- The 40s and 50s age group shows the highest level of interest.
- A large proportion access the drugs through private prescriptions rather than the NHS.
In conclusion, researchers emphasize that while the jabs are powerful agents for shedding pounds, they are not a standalone solution and lasting health benefits relies on combined lifestyle management.
